Our focus is on developing innovative strategies to regenerate and rehabilitate functional muscle tissue following traumatic injuries, specifically volumetric muscle loss. The regenerative approach we are pursuing involves the use of multifunctional biomaterials that enhance muscle regeneration and function. These biomaterials are composed of extracellular matrix proteins that are chemically cross-linked and processed in the form of biosponges, hydrogels, or micro- or nano-particles for various applications. Not only do these biomaterials provide mechanical support, but they also deliver growth factors, pharmaceuticals, stem cells, and exosomes to targeted areas, suppress immune responses, and act as a substrate for host cell infiltration and proliferation. Additionally, we are exploring rehabilitative strategies, such as neuromuscular electrical stimulation, to improve muscle mass and strength. Ongoing research is investigating the synergistic effect of combining regenerative and rehabilitative strategies to optimize their efficacy.

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